The variation of BCG vaccine efficacy justifies a second dose?

An integrative review

Authors

DOI:

https://doi.org/10.51723/ccs.v33i01.942

Keywords:

BCG Vaccine, Tuberculosis, Secondary Immunization, Vaccination

Abstract

Aims: analyze effectiveness of BCG vaccine, the possibility of applying a second dose and new tuberculose prevention strategies. Method: integrative review. Selection of articles in BVS, Lilacs and MEDLINE databases and use of descriptors ‘BCG Vaccine’ AND ‘Tuberculosis’ AND ‘Secondary Immunization’ AND ‘Vaccination’. The choice of articles went through filter application, title and abstract analysis, and full reading, resulting in 14 articles. Results: for an alternative to improve the performance of the single dose, there are boosters and revaccination. Conclusion: it is necessary to develop further studies on the applicability of the second dose considering geoeconomic factors. For now, WHO does not recommend this practice.

Downloads

Download data is not yet available.

Author Biographies

Giovana Knapik Batista, Faculdades Pequeno Príncipe

Estudante do Curso de Graduação em Medicina. Faculdades Pequeno Príncipe, Curitiba, Paraná, Brasil

Oona Salomão Erdmann, Faculdades Pequeno Príncipe

Estudante do Curso de Graduação em Medicina. Faculdades Pequeno Príncipe, Curitiba, Paraná, Brasil

Alanis Carolina Guimarães, Faculdades Pequeno Príncipe

Estudante do Curso de Graduação em Medicina. Faculdades Pequeno Príncipe, Curitiba, Paraná, Brasil

Matheus Corrêa, Faculdades Pequeno Príncipe

Estudante do Curso de Graduação em Medicina. Faculdades Pequeno Príncipe, Curitiba, Paraná, Brasil

Thayná Vitória Zazzera de Moraes, Faculdades Pequeno Príncipe

Estudante do Curso de Graduação em Medicina. Faculdades Pequeno Príncipe, Curitiba, Paraná, Brasil

Laercio Dante Stein Piancini, Faculdades Pequeno Príncipe

Mestre e Doutor em Genética. Graduado em Ciências Biológicas pela Universidade Federal do Paraná. Docente no curso de Medicina das Faculdades Pequeno Príncipe, Curitiba, Paraná, Brasil.

References

Principi N, Esposito S. The present and future of tuberculosis vaccinations. Tuberculosis (Edinb). 2015; 95(1):6-13. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1472979214205701?via%3Dihub. https://doi.org/10.1016/j.tube.2014.10.004 .

Furin J, Cox H, Pai M. Tuberculosis. Lancet. 2019 Apr 20;393(10181):1642-1656. doi: 10.1016/S0140-6736(19)30308-3. Epub 2019 Mar 20. PMID: 30904262 .

Dey B, Jain R, Gupta U, Katoch VM, Ramanathan VD, Tyagi A. A Booster Vaccine Expressing a Latency-Associated Antigen Augments BCG Induced Immunity and Confers Enhanced Protection against Tuberculosis. PLoS One. 2011; 6(8):8. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023360.

https://doi.org/10.1371/journal.pone.0023360

Goldman, L. et al. Cecil Medicina. 24. Ed. Rio de Janeiro: Elsevier; 2014.

Arruda, Karla Gleice de. Avaliação dos custos do tratamento de tuberculose em município de médio porte do nordeste brasileiro. MS thesis. Universidade Federal de Pernambuco, 2014.

Barreto M. L., Pereira S. M., Ferreira A. A. Vacina BCG: eficácia e indicações da vacinação e da revacinação / BCG vaccine: efficacy and indications for vaccination and revaccination. J. pediatr. 2006; 8 2(3): s45-s54. https://doi.org/10.1590/S0021-75572006000400006

Dye C. Making wider use of the world’s most widely used vaccine: Bacille Calmette Guérin revaccination reconsidered. J R Soc Interface. 2013; 10(87):8. Available from: https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2013.0365 .

https://doi.org/10.1098/rsif.2013.0365

Siddiqui KF, Amir M, Khan N, Rama Krishna G, Sheikh JA, Rajagopal K, et al. Prime boost vaccination strategy with bacillus Calmette-Guérin (BCG) and liposomized alpha crystalline protein 1 reinvigorates BCG potency. Clin Exp Immunol. 2015; 181(2):286-296. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/cei.12634. https://doi.org/10.1111/cei.12634 .

Montagnani C., Chiappini E., Galli L., Martino M. Vaccine against tuberculosis: what's new? BMC Infectious Diseases. 2014; 14 (Suppl 1): S2. doi: 10.1186/1471-2334-14-S1-S2.

Sadagopal S., Braunstein M., Hager C. C., Wei J., Daniel A. K., Bochan M. R. et al. Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PLoS ONE. 2009; 4 (5): e5531. https://doi.org/10.1371/journal.pone.0005531

Gupta N, Garg S, Vedi S, Kunimoto DY, Kumar R, Agrawal B. Future path toward TB vaccine development: Boosting BCG or re-educating by a new subunit vaccine. Front Immunol. 2018;9(OCT):1–17. doi: 10.3389/fimmu.2018.02371

Barreto ML, Pereira SM, Pilger D, Cruz AA, Cunha SS, Sant’Anna C, Ichihara MY, et al. Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: Second report of the BCG-REVAC cluster-randomised trial. Vaccine. 2011; 29(31):4875-4877. Available from: https://reader.elsevier.com/reader/sd/pii/S0264410X1100733X?token=BD01525BE2EF44312

F581861803C9E936DD4C8CB7950BC2326CEF2C3D734DD93A6DC00639CC65154EE 80CB09B6A1B7 . https://doi.org/10.1016/j.vaccine.2011.05.023.

Antas P. R. Z., Castello-Branco L. R. R. New vaccines against tuberculosis: lessons learned from BCG immunisation in Brazil. Trans R Soc Trop Med Hyg. 2008: 102 (7): 628-30. doi: 10.1016/j.trstmh.2008.03.014

Saqib M, Khatri R, Singh B, Gupta A, Kumar A, Bhaskar S. Mycobacterium indicus pranii as a booster vaccine enhances BCG induced immunity and confers higher protection in animal models of tuberculosis. Tuberculosis [Internet]. 2016;101:164–73. Available from: http://dx.doi.org/10.1016/j.tube.2016.10.002

Nemes E, Geldenhuys H, Rozot V, Rutkowski KT, Ratangee F, Bilek N, et al. Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination . N Engl J Med. 2018;379(2):138–49. http://dx.doi.org/10.1056/NEJMoa1714021

Suliman S, Geldenhuys H, Johnson JL, Hughes JE, Smit E, Murphy M, et al. Bacillus Calmette–Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses. J Immunol. 2016;197(4):1100–10. doi: 10.4049/jimmunol.1501996.

Glynn, Judith R., et al. The effect of BCG revaccination on all-cause mortality beyond infancy: 30-year follow-up of a population-based, double-blind, randomised placebo-controlled trial in Malawi. The Lancet Infectious Diseases 21.11 (2021): 1590-1597. https://doi.org/10.1016/S1473-3099(20)30994-4

World Health Organization. BCG vaccines: WHO position paper – February 2018. Vaccins

BCG: Note de synthèse de l’OMS – Février 2018. Genebra: World Health Organization, 2018. 24 p. Disponível em: https://apps.who.int/iris/bitstream/handle/10665/260306/WER9308.pdf?sequence=1 . Acesso em: 10 jan. 2021.

Published

2022-03-11

How to Cite

1.
Knapik Batista G, Salomão Erdmann O, Guimarães AC, Corrêa M, Zazzera de Moraes TV, Stein Piancini LD. The variation of BCG vaccine efficacy justifies a second dose? : An integrative review. Com. Ciências Saúde [Internet]. 2022 Mar. 11 [cited 2024 Jul. 3];33(01). Available from: https://revistaccs.escs.edu.br/index.php/comunicacaoemcienciasdasaude/article/view/942

Issue

Section

Clínica Assistencial